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M.R.P.: ₹38360
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tenectase activator is a fibrin-specific tissue-plasminogen activator. it binds to fibrin-rich clots and promotes thrombolysis by converting plasminogen to plasmin. plasmin, in turn, degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. tenectase activator injection is also known as “clot-buster” because it dissolves harmful blood clots that cause strokes (if th
hypersensitivity reactions to the tenectase activator or any excipients
significant bleeding disorder either at present or within the past 6 months
patients receiving effective oral anticoagulant treatment, e.g.
warfarin sodium (inr > 1.3) any history of central nervous system damage (i.e.
neoplasm, aneurysm, intracranial or spinal surgery)
known haemorrhagic diathesis
severe uncontrolled hypertension
recent trauma to the head or cranium
prolonged cardiopulmonary resuscitation (> 2 minutes) within the past 2 weeks
acute pericarditis and/or subacute bacterial endocarditis
acute pancreatitis
severe hepatic dysfunction, including hepatic failure, cirrhosis, portal hypertension (oesophageal varices) and active hepatitis
active peptic ulceration
arterial aneurysm and known arterial/venous malformation
neoplasm with increased bleeding risk
any known history of haemorrhagic stroke or stroke of unknown origin
known history of ischaemic stroke or transient ischaemic attack in the preceding 6 months
dementia.
babies: not applicable.
lactating mothers: tenectase activator injection should be used with caution during breastfeeding.
it would be best to hold breastfeeding until the mother's treatment is completed and the drug is eliminated from her body.
pregnancy: tenectase activator injection is considered unsafe to use during pregnancy.
however, there are limited studies in humans, and animal studies state that the drug has harmful effects on the developing baby.
please consult your doctor.
driving: this tenectase activator injection is intended for use in hospitalized patients.
alcohol: no information is available on whether it is safe to consume alcohol along with this injection.
please consult your doctor.
liver: limited information is available about the use of this tenectase activator injection in patients with liver disease.
please consult your doctor.
kidney: limited information is available about the use of this tenectase activator injection in patients with kidney disease.
please consult your doctor..
injection site bleeding nosebleeds blood in stool blood in urine gastrointestinal bleeding.
tenectase activator is a fibrin-specific tissue-plasminogen activator.
it binds to fibrin-rich clots and promotes thrombolysis by converting plasminogen to plasmin.
plasmin, in turn, degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action..
consult your doctor immediately if you missed the dose of tenectase activator injection.
• tenectase activator injection is prescribed to treat acute ischaemic stroke within 3 hours of the onset of symptoms • it is given as an injection into the vein under the supervision of a physician • it may increase your risk of bleeding. inform your doctor immediately if you notice bleeding at the injection site, nose bleed, and blood in the urine • continue with your diet and exercise along with previously prescribed medications for heart attack.
contraindicated • tenectase activator + defibrotide: defibrotide increases effects of teneceplase by pharmacodynamic synergism • tenectase activator + prothrombin complex concentrate, human: prothrombin decreases effects of teneceplase by pharmacodynamic antagonism serious • tenectase activator + apixaban: concurrent use of these drugs increases anticoagulation • tenectase activator + warfarin: concurrent use of these drugs increases anticoagulation • tenectase activator + reteplase: concurrent use of these drugs increases anticoagulation monitor closely • tenectase activator + antithrombin iii: concurrent use of these drugs increases anticoagulation.
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