Apigat 5mg 30 Tablets

Babies: Not applicable. Lactating mothers: Apigat tablet is considered unsafe to use during breastfeeding, and limited human data state that the drug may pass into breast milk and harm the baby.
Pregnancy: Apigat tablet is considered safe to use during pregnancy. Animal studies state that the drug has shown low or no adverse effects on the developing baby.
However, there are limited studies. Driving: It is safe to drive while taking this medication as it does not usually affect your driving ability.
Alcohol: Caution is advised while consuming alcohol along with this tablet. Please consult your doctor.
Kidney: Apigat tablets should be used with caution in patients with kidney disease. Dose adjustment of this medication is required for patients.
Please consult your doctor. Liver: Apigat tablet should be used with caution in patients with liver disease.
Dose adjustment of this medication is required for patients. Please consult your doctor.
Dose adjustment is not required in patients with mild liver disease..

Bleeding.

Apigat is in a class of medications called factor xa inhibitors that works by inhibiting factor xa that prevents the conversion of prothrombin to thrombin, which prevents cross-linked blood clots of fibrin formation..

If you miss a dose, take it as soon as possible. If it is near the time of the next dose, then skip the missed dose.
Take the prescribed dose on your regular time daily. Don't double the dose to catch up with the missed dose..

• For appropriate benefit, continue to take the medication at the same time every day. It is preferred to take at night with meals • It interacts less with food or other medicines.
Hence, frequent dose changes are not required • It increases your risk of bleeding. Be cautious while shaving, cutting fingernails or toenails, using sharp objects, or engaging in contact sports (e.G.
Football, wrestling) • Inform your doctor if you notice blood in your vomit, urine, or stool (black, tarry stools or bright red blood) • Quit the medication if you are planned to have surgery or dental treatment • Inform your doctor if you have any kidney problem • Don’t quit the medication without talking to your doctor.

Contraindicated • Apigat + Mifepristone: Mifepristone increases toxicity of apigat by anticoagulation • Apigat + Rifabutin: Rifabutin will decrease the level or effect of apigat by affecting hepatic/ intestinal enzyme cyp3a4 metabolism • Apigat + Fondaparinux: Concurrent use of these drugs increases anticoagulation • Apigat + Phenytoin: Phenytoin will decrease the level or effect of apigat by affecting hepatic/ intestinal enzyme cyp3a4 metabolism Serious • Apigat + Alteplase: Concurrent use of these drugs increases anticoagulation • Apigat + Atazanavir: Atazanavir will increase the level or effect of apigat by affecting hepatic/ intestinal enzyme cyp3a4 metabolism • Apigat + Mefenamic acid: Concurrent use of these drugs increases anticoagulation.